Journal: Parkinson's Disease

Article Title: Neuroinflammation and Myelin Status in Alzheimer's Disease, Parkinson's Disease, and Normal Aging Brains: A Small Sample Study

doi: 10.1155/2019/7975407

Figure Lengend Snippet: Astrocytes and microglia in the striatal tissue sections using GFAP and Iba1 antibodies. (a) Representative images of activated astrocytes and microglia in white matter, gray matter, and striatum. The activated astrocytes showed enlarged cell bodies and enlongated fibers, while activated microglia showed meatball-like appearance with enlarged cell bodies and shortened processes. The scale bar represents 100 μ m. (b, c) The quantitative analysis of the GFAP and Iba1 expression in white matter in the astrocytosis and the nonastrocytosis groups. The bars represent mean ± SEM. ∗ represents p < 0.05.

Article Snippet: Histologic stains included hematoxylin and eosin, Luxol fast blue and Cresyl echt violet (NeuronMyelinStain), and Bielschowsky silver staining (Hitobiotec Corp. Kingsport, TN, USA).

Techniques: Expressing

Journal: International Journal of Molecular Sciences

Article Title: Boosting Acetylcholine Signaling by Cannabidiol in a Murine Model of Alzheimer’s Disease

doi: 10.3390/ijms252111764

Figure Lengend Snippet: CBD inhalation reduced senile plaques in AD. Using the Bielschowsky staining, nerve fibers, neurofibrillary tangles, and senile plaques in the central nervous system were measured. Inhaled CBD significantly reduced senile plaques (amyloid plaques, yellow arrows) and neurofibrillary tangles (in black/dark brown) in AD mice compared to mice treated with placebo.

Article Snippet: Serial 8 μm coronal brain sections were cut using a sliding microtome and then sections were deparaffinized prior to staining with a Bielschowsky Stain Kit (Polysciences, Warrington, PA, USA, cat# 25994-250).

Techniques: Staining